HIGH-THROUGHPUT GENE EXPRESSION
TECHNOLOGY

Access a new generation of spatially-resolved Transcriptomics, through our combination of state-of-the-art sequencing technology and high resolution microscopy. All mRNAs with spatial resolution in a single experiment.

THE CONCEPT

The Spatial Transcriptomics Technology places arrayed reverse transcription primers with a built-in barcode, one for each spatial position, on the surface of a glass slide.

When cutting a thin section of a tissue and placing it on top of the glass slide with such primers, reverse transcription captures the information at its origin – the native tissue.

After cleavage and Library preparation the captured  RNA molecules are sequenced using standard Illumina Sequencing.

See an illustration of the technology here.

More content coming soon.

WORKFLOW

Our innovative approach is to combine state-of-the-art sequencing technologies with high resolution microscopy. For more information on the process see our WORKFLOW

YOU ASKED

What is the advantage of adding spatial resolution to RNA-Seq experiments?
Ever tried navigating through an unknown city without a map? This is what traditional RNA-Seq in tissues can look like today. For the first time Spatial Transcriptomics provides a map by combining histology and full mRNA analysis in an innovative way.

Do I need to invest in new equipment to perform Spatial Transcriptomics?
No, we have found that laboratories have all the major infrastructure required for Spatial Transcriptomics in place. For a comprehensive list of instruments and reagents needed for the protocol see RESOURCES.

What is the current resolution of your Library Preparation glass slides?
Our glass slides contain 1007 spots with a diameter of 100 μm and a center to center distance 200 μm. This gives a comprehensive overview of a tissue’s architecture while maintaining high sample throughput and limited sequencing costs.

CONTACT

SWEDEN

Södra Fiskartorpsvägen 15 C
Stockholm, 11433

SUPPORT

SALES
sales@spatialtranscriptomics.com

SUPPORT
support@spatialtranscriptomics.com

 

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